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Matt Carson


Matthew B. Carson, PhD
Head, Digital Systems/Senior Research Data Scientist
Ward 2-321
Phone: (312) 503-5321
Email Matt
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Matt develops and applies data collection, processing, analysis, and mining methods to facilitate knowledge discovery in biomedical informatics research. He believes that bridging the gap between biological and clinical research is crucial to understanding human health and disease, and that success requires data integration within and across domains. Trained as a bioinformatician, he has experience in designing and building genome annotation and comparative genomics pipelines, complex network analysis, and machine learning research. He has worked with collaborators to find new methods for knowledge acquisition from electronic health record data and has designed a novel graph-based framework for quantifying and measuring provider collaboration based on patient outcomes. He has developed, directed, and taught data science courses in the Driskill Graduate Program, the Health Sciences Integrated Program, and the Master of Science in Clinical Investigation Program at Northwestern University. In his current role as the Head of Galter's Digital Systems Department, Matt leads the DataLab, a research support core that develops and designs novel, sustainable data services throughout all stages of the research data life cycle. He is also the Northwestern Project Lead for InvenioRDM, a multi-site collaborative project led by CERN to build a turn-key, next-generation research data management platform. 

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Recent Presentations, Abstracts, and Workshops

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  • Chandler, A. E., Mutharasan, R.K., Amelia, L., Carson, M. B., Scholtens, D. M., Soulakis, N. D. Methods of Information in Medicine 58(2-3):71-78 01 Jan 2019, doi: 10.1055/s-0039-1694990.
  • Jia, C., Carson, M. B., Wang, X., Yu, J. Concept Decompositions for Short Text Clustering by Identifying Word Communities, Pattern Recognition (2017), doi: 10.1016/j.patcog.2017.09.045.
  • Luo, Y., Thompson, W. K., Herr, T. M., Zeng, Z., Berendsen, M. A., Jonnalagadda, S. R., Carson, M. B., Starren, J. Natural Language Processing for EHR-Based Pharmacovigilance: A Structured Review. Drug Saf. 2017 Jun 22. doi: 10.1007/s40264-017-0558-6. [Epub ahead of print]. PMID: 28643174
  • Jia, C., Li, Y., Carson, M. B., Wang, X., and Yu, J. Node Attribute-enhanced Community Detection in Complex Networks. Scientific Reports. 2017, 7 (2626). doi: 10.1038/s41598-017-02751-8. PMID: 28572625
  • Carson, M. B., Liu, C., Lu, Y., Jia, C., and Lu, H. A Disease Similarity Matrix based on the Uniqueness of Shared Genes. BMC Medical Genomics 2017, 10(Suppl 1):26.
    doi: 10.1186/s12920-017-0265-2. PMID: 28589854
  • Carson, M. B., Scholtens, D. M., Frailey, C. N., Gravenor, S. J., Powell, E. S., Wang, A. Y., Kricke, G. S., Ahmad, F. S., Mutharasan, R. K., and Soulakis, N. D. Characterizing Teamwork in Cardiovascular Care Outcomes: A Network Analytics Approach. Circ Cardiovasc Qual Outcomes. 2016 Nov; 9(6): 670–678. doi: 10.1161/CIRCOUTCOMES.116.003041. PMID: 28051772
  • Carson, M. B., Gravenor, S. J., Scholtens, D. M., Frailey, C. N., Kricke, G. S., and Soulakis, N. D. An outcome-weighted network model for characterizing collaboration. PLoS ONE. 2016 Oct 5. doi: 10.1371/journal.pone.0163861. PMID: 27706199
  • Kricke, G. S., Carson, M. B., Lee, Y., Benacka, C., and Soulakis, N. D. Leveraging Electronic Health Record Documentation for Failure Mode and Effects Analysis Team Identification on an Inpatient Cardiology Unit. J Am Med Inform Assoc. 2016 Sep 1. pii: ocw083. doi: 10.1093/jamia/ocw083. PMID: 27589944
  • Qin, W., Zhao, G., Carson, M. B., Jia, C., and Lu, H. Knowledge-based three-body potential for transcription factor binding site prediction. IET Syst. Biol. 2016 Feb;10(1):23-9. doi: 10.1049/iet-syb.2014.0066. PMID: 26816396
  • Carson, M. B., Gu, J., Yu, G., and Lu, H. Identification of Cancer-related Genes and Motifs in the Human Gene Regulatory Network. IET Syst. Biol. 2015, Aug;9(4):128-34. doi: 10.1049/iet-syb.2014.0058. PMID: 26243828
  • Carson, M. B. and Lu, H. Network-based Prediction and Knowledge Mining Of Disease Genes. BMC Medical Genomics 2015, 8 (Suppl 2):S9. doi: 10.1186/1755-8794-8-S2-S9. PMID: 26043920
  • Soulakis, N., Carson, M. B., Lee, Y. J., Schneider, D. H., Skeehan, C. T., and Scholtens, D. M. Visualization of multidisciplinary, collaborative care for hospitalized heart failure patients. J Am Med Inform Assoc, Special Issue on Visual Analytics in Healthcare. 2015 Feb 20. doi:10.1093/jamia/ocu017. PMID: 25710558
  • Jia, C., Carson, M. B., Wang, Y., Lin, Y., and Lu, H. A New Exhaustive Method and Strategy for Finding Motifs in ChIP-enriched Regions. PLoS ONE. 2014, 9(1): e86044. PMID: 24475069
  • Lu, Y., Deng, J., Carson, M. B., Lu, H., and Lu, L. J. Computational methods for the prediction of microbial essential genes. Current Bioinformatics. 2013, 9(2):89-101.
  • Jia, C., Carson, M. B., and Yu, J. A Fast Weak Motif-Finding Algorithm Based on Community Detection in Graphs. BMC Bioinf. 2013, 14:227. doi:10.1186/1471-2105-14-227. PMID: 23865838
  • Siddaramappa, S., Challacombe, J. F., Duncan, A. J., Gillaspy, A. F., Carson, M. B., Gipson, J., Orvis, J., Zaitshik, J., Barnes, G., Bruce, D., Chertkov, O., Detter, J. C., Han, C. S., Tapia, R., Thompson, L. S., Dyer, D. W., and Inzana, T. J. Horizontal gene transfer in Histophilus somni and its role in the evolution of pathogenic strain 2336, as determined by comparative genomic analyses. BMC Genomics. 2011 Nov 23;12:570. doi:10.1186/1471-2164-12-570. PMID: 22111657
  • Carson, M. B., Langlois, R., and Lu, H. NAPS: A Residue-level Nucleic Acid-binding Prediction Server. Nucleic Acids Res. 2010. Jul; 38 (Web Server issue):W431-5. doi:10.1093/nar/gkq361. PMID: 20478832
  • Bhardwaj, N., Carson, M. B., Abyzov, A., Yan, K., Lu, H., and Gerstein, M. B. Analysis of Combinatorial Regulation: Scaling of Partnerships between Regulators with the Number of Governed Targets. PLoS Comput. Biol. 2010 May 27; 6(5): e1000755. doi:10.1371/journal.pcbi.1000755. PMID: 20523742
  • Carson, M. B., Langlois, R., and Lu, H. Mining Knowledge for the Methylation Status of CpG Islands Using Alternating Decision Trees, Engineering in Medicine and Biology Society, 2008. EMBS 2008. 30th Annual International Conference of the IEEE, 20-25 Aug. 2008 Page(s):3787–3790. PMID: 19163536
  • Zhao, G., Carson, M. B., and Lu, H.  Prediction of specific protein-DNA recognition by knowledge-based two-body and three-body interaction potentials. Engineering in Medicine and Biology Society, 2007. EMBS 2007. 29th Annual International Conference of the IEEE, 22-26 Aug. 2007 Page(s):5017-5020. PMID: 18003133
  • Langlois, R. E., Carson, M. B., Bhardwaj, N., and Lu, H.  Learning to translate sequence and structure to function: identifying DNA-binding and membrane binding proteins.  Annals of Biomedical Engineering.  2007 Jun; 35(6):1043-1052. PMID: 17436108
  • Harrison, A., Dyer, D. W., Gillaspy, A. F., Ray, W. C., Mungur, R., Carson, M. B., Gipson, J., Gipson, M., Johnson, L. S., Lewis, L., Bakaletz, L. O., and Munson, R. S. Jr. Genomic sequence of an otitis media isolate of nontypeable Haemophilus influenzae:  a comparative study with Haemophilus influenzae serotype d, strain KW20.  J. Bacteriol. 2005 Jul;187(13):4627-36.  PMID: 15968074
  • Ducey, T. F., Carson, M. B., Orvis, J., Stintzi, A. P., and Dyer, D. W. Identification of the Iron-Responsive Genes of Neisseria gonorrhoeae by Iron-limitation Gene Analysis in Defined Medium.  J. Bacteriol. 2005 Jul;187(14):4865-74. PMID: 15995201
  • Munson, R. S. Jr., Harrison, A., Gillaspy, A., Ray, W. C., Carson, M. B., Armbruster, D., Gipson, J., Gipson, M., Johnson, L., Lewis, L., Dyer, D. W., and Bakaletz L. O.  Partial analysis of the genomes of two nontypeable Haemophilus influenzae otitis media isolates.  Infect Immun.  2004 May; 72(5):3002-10. PMID: 15102813
  • Ajdic, D., McShan, W. M., McLaughlin, R. E., Savic, G., Chang J., Carson, M. B., Primeaux, C., Tian, R., Kenton, S., Jia, H., Lin, S., Qian, Y., Li, S., Zhu, H., Najar, F., Lai, H., White, J., Roe, B. A., and Ferretti. J. J. Genome sequence of Streptococcus mutans UA159, a cariogenic dental pathogen.  Proc Natl Acad Sci USA.  2002 Oct 29; 99(22):14434-9.  Epub 2002 Oct 23.  PMID: 12397186
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Updated: July 23, 2020