Finding Evidence-based Answers to Clinical Questions - Quickly and Effectively


I need: Example: Resources to consider:

an overview of a particular disease, condition

background information

What's the difference between depression and bipolar disorder?

I have a new patient with sickle cell anemia; I need an overview of this condition.

Textbooks (print or online)



drug information

What is the pediatric dosage of erythromycin for strep throat?

What drugs have been approved by the FDA for the tx of Alzheimer's?

Clinical Pharmacology Online


AHFS Drug Information

PubMed or Embase for more specific information

a synthesis of best practice recommendations for disease management

(critically-appraised topics)

What's the latest on the management of panic disorder?

What's the best method of pain control in children?

Cochrane Library

PubMed Clinical Queries – Systematic Reviews

National Guideline Clearinghouse

PubMed (Filter to “Practice Guideline” article type)

TRIP [simultaneously searches multiple evidence-based resources]

an answer to a narrow question that isn’t addressed in the synthesis resources

(critically-appraised articles and unfiltered information)

In a 70 year old woman with primary insomnia and a previous adverse reaction to hypnotics, can cognitive behavior therapy improve sleep quality and duration?

In a toddler with croup, does dexamethasone (or other glucocorticoids) reduce symptoms better than standard supportive care?

PubMed Clinical Queries – Clinical Study Category

ACP Journal Club

TRIP [simultaneously searches multiple evidence-based resources]

evidence-based information about alternative therapies

Is melatonin safe and effective for treating insomnia?

Does music therapy help surgical patients heal faster?

PubMed (Filter to “Complementary Medicine” Subject under Other Filters and “RCT” Article type)

Alternative Medicine GalterList

TRIP [simultaneously searches multiple evidence-based resources]

cutting edge information that isn’t yet published in the journal literature (not necessarily evidence-based)

My patient heard about a new drug for xxxx on 20-20 last night. It’s brand new and not in CPO or MEDLINE. Where can I find more information about it?

News Resources (Lexis-Nexis Academic)

Web Resources (Google; Google Scholar)

information to share with patients

Where can I find some nutrition information for my newly-diagnosed patient with diabetes?


Patient Education handouts in ClinicalKey (formerly MD Consult)

Health Information from NMH HLC


Adapted from

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Updated: April 27th, 2017 11:39